منابع مشابه
Mitochondrial Haplogroups Define Two Phenotypes of Osteoarthritis
OBJECTIVE To assess a mitochondrion-related phenotype in patients with osteoarthritis (OA). METHODS Serum levels of the following OA-related biomarkers: matrix metalloproteinase-1 (MMP-1); MMP-3; MMP-13; myeloperoxidase (MPO); a peptide of the alpha-helical region of type II collagen, Coll2-1, and its nitrated form Coll2-1NO(2); a C-terminal neoepitope generated by the collagenase-mediated cl...
متن کاملClassification of osteoarthritis phenotypes by metabolomics analysis
OBJECTIVES To identify metabolic markers that can classify patients with osteoarthritis (OA) into subgroups. DESIGN A case-only study design was utilised. PARTICIPANTS Patients were recruited from those who underwent total knee or hip replacement surgery due to primary OA between November 2011 and December 2013 in St. Clare's Mercy Hospital and Health Science Centre General Hospital in St. ...
متن کاملAdaptive evolution of molecular phenotypes
Molecular phenotypes link genomic information with organismic functions, fitness, and evolution. Quantitative traits are complex phenotypes that depend on multiple genomic loci. In this paper, we study the adaptive evolution of a quantitative trait under time-dependent selection, which arises from environmental changes or through fitness interactions with other co-evolving phenotypes. We analyz...
متن کاملThe Value of Phenotypes in Knee Osteoarthritis Research
Background Over the past decade, phenotypes have been used to help categorize knee osteoarthritis patients relative to being subject to disease, disease progression, and treatment response. A review of potential phenotype selection is now appropriate. The appeal of using phenotypes is that they most rely on simple physical examination, clinically routine imaging, and demographics. The purpose o...
متن کاملAssociation of a nsSNP in ADAMTS14 to some osteoarthritis phenotypes.
OBJECTIVE To investigate the effect in OA (Osteoarthritis) susceptibility of putative damaging changes in ADAM (A Disintegrin And Metalloprotease) and ADAMTS (ADAM with ThromboSpondin motif) proteases. METHODS Non-synonymous single nucleotide polymorphisms (nsSNP) in 18 ADAMTS and 31 ADAM genes were analyzed with two software applications for prediction of functional damage. Four putative dam...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2018
ISSN: 1063-4584
DOI: 10.1016/j.joca.2018.02.376